Shamili hails from an acting family, being the younger sister of actor Richard aka Rishi in Tollywood and actress Shalini and the sister-in-law of actor Ajith Kumar. She started acting at the age of two. She came to prominence after acting in Kannada, Malayalam films as a child, and then in Tamil following her performance in Mani Rathnam's 'Anjali', in which she portrayed a mentally challenged child, which garnered her the National Film Award for Best Child Artist.In 1992, she acted in Bharathan's Malooty which won her many appreciation. She also acted as a teenager in Fazil's Harikrishnans as Mammooty and Mohanlal's little sibling. In kannada she made Dakshayini, Kadambari (1993), Karulina Kudi (1995), Bhairavi (1991), Chinna Nee Naguthiru (1993). She stopped acting in kannada 10 years ago, but still she is the famous child actress. She has been cast in Anand Ranga's directorial debut alongside Siddarth. Anand Ranga worked as an associate to 'Bommarillu'. She also stars as Mohanlal's daughter in a yet-to-be-titled movie.